Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential
نویسندگان
چکیده
منابع مشابه
Deguelin, a plant-derived rotenoid, mediates potent chemopreventive responses through transcriptional regulation of phorbol ester-induced
Deguelin, a plant-derived rotenoid, mediates potent chemopreventive responses through transcriptional regulation of phorbol ester-induced ornithine decarboxylase (ODC) activity. To explore the mechanism of this effect, the activity of this compound was evaluated with a number of modelsystems.Usingculturedmouseepidermal308cells,thesteady-state levels of both 12-0-tetradecanoylphorbol-13-acetate ...
متن کاملCancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid.
Deguelin, a natural product isolated from Mundulea sericea (Leguminosae), was shown previously to mediate strong inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ornithine decarboxylase (ODC) activity in cell culture and to reduce the formation of preneoplastic lesions when mouse mammary glands were exposed to 7,12-dimethylbenz(a)anthracene. As reported currently, deguelin was s...
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ژورنال
عنوان ژورنال: Cancer
سال: 2019
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.32069